Ever since I was a PhD student, I received a constant flow of unnegotiated job applications by e-mail, asking me for open university positions as PhD students, Postdocs, or interns. Those e-mails are sent by people whom I do not know, and they have all the characteristics of unnegotiated bulk e-mail, aka spam. However, it seems that the people sending these mails are genuine in their intentions, and some of them even express their frustration about sending hundreds of such mails and never receiving an answer.
Of course, I can not speak for other people holding university positions. I can only describe my own view of the issue, which mainly includes two situations:
When you send unnegotiated applications nonetheless, please be aware that you are not the only one. Seen with the eyes of most university employees, you simply contribute to the bulk of spam e-mail that we receive every day. Thus, don't be disappointed if you don't receive an answer.